May 21, 2007—A study published in The New England Journal of Medicine showed that Avandia significantly increased the risk of heart attacks, as compared to other diabetes drugs or a placebo.
Dr. Steven Nissen reviewed more than 40 clinical studies involving 28,000 patients. He estimates that tens of thousands of people had heart attacks as a result of Avandia.
GlaxoSmithKline has been aware of these concerns since at least August 2006 when it conducted a similar analysis. Notwithstanding its own analysis, GlaxoSmithKline defended the safety of Avandia and claimed the drug has a comparable cardiovascular profile to other oral antidiabetic medicines. |